Fibri(nogen) drives repair after acetaminophen-induced liver injury via leukocyte αMβ2 integrin-dependent upregulation of MMP12
A team of MSU researchers has uncovered a new pathway in the body that stimulates liver repair. Using an experimental model of high-dosage acetaminophen, the team found that liver injury activated blood clotting, which then stimulated liver repair. Acetaminophen is the active ingredient in more than 600 medications and is a leading cause of drug-induced liver failure in the United States if used above the recommended dosage.
“This pathway of repair has never been described before and could lead to new strategies to promote liver repair,” said Luyendyk, an associate professor of pathobiology and diagnostic investigation...
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