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    Adaptive Immune Responses tagged posts

    Study shows that Adaptive Immune Responses can cause Cellular Loss in the Aging-Related Brain

    November 8, 2022, Categories  Biology/Biotechnology, Health/Medical

    Study shows that adaptive immune responses can cause cellular loss in the aging brain
    The cell type composition of scRNA-seq was analyzed and oligodendrocytes were separated into four different sub-clusters. Two previously unknown oligodendrocyte clusters appeared in aged mice, which were enriched in the white matter. One was associated with injury responses. Because this cluster was highly enriched in the aged white matter, it was named aging-related oligodendrocytes (Fig. 1b-c, e). Also a smaller interferon-responsive oligodendrocyte subpopulation (IRO) was characterized by the expression of genes commonly associated with an interferon response. Credit: Kaya et al.

    Past neuroscience studies have consistently demonstrated that the aging of the mammalian nervous system is liked with a decline in the volume and functioning of white matter, nerve fibers found in deep brai...

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