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Changes in Brain Connectivity Protect against Developing Bipolar Disorder

Brain composition and bipolar disorder. MRI studies indicate many compositional differences between brains of individuals with bipolar disorder and individuals without. This supports the idea that bipolar disorder is a confluence of both environmental and biological factors. Credit: Bipolar Lives.

Brain composition and bipolar disorder. MRI studies . Credit: Bipolar Lives.

Naturally occurring changes in brain wiring can help patients at high genetic risk of developing bipolar disorder avert the onset of the illness, according to a new study led by researchers at the Icahn School of Medicine at Mount Sinai. The study’s findings open up new avenues for researchers to explore ways the brain can prevent disease expression, also known as resilience, with the hope of developing better treatments.

Bipolar disorder, also known as manic-depressive illness, is a brain disorder that causes fluctuations in patients’ mood, energy, activity levels and the ability to carry out day-to-day tasks. Bipolar disorder is highly heritable.

Researchers used MRI to map the connectivity patterns in the brain...

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