adenosine tagged posts

OHSU Scientists Identify Molecule that could help Treat Parkinson’s

Locomotion activates PKA through dopamine and adenosine in striatal neurons  | Nature
: In vivo PKA activity imaging reveals cell-type-specific modulation of PKA by dopamine.

Discovery could immediately suggest new avenues for drug development. Researchers at Oregon Health & Science University have discovered that the neurotransmitter adenosine effectively acts as a brake to dopamine, another well-known neurotransmitter involved in motor control.

Scientists found that adenosine operates in a kind of push-pull dynamic with dopamine in the brain; the discovery published today in the journal Nature.

“There are two neuronal circuits: one that helps promote action and the other that inhibits action,” said senior author Haining Zhong, Ph.D., scientist with the OHSU Vollum Institute...

Read More