ADHD tagged posts

The Neuropsychiatric Disease-Associated Gene cacna1c Mediates Survival of Young Hippocampal Neurons

A new study shows the death of newborn brain cells may be linked to a genetic risk factor for schizophrenia, bipolar disorder, autism, ADHD, and depression, and at the same time shows a compound currently being developed for use in humans may have therapeutic value for these diseases by preventing the cells from dying.

In 2013, the largest genetic study of psychiatric illness to date implicated mutations in the gene called CACNA1C as a risk factor in 5 major forms of neuropsychiatric disease. All the conditions also share the common clinical feature of high anxiety...

This is an image of a human brain, courtesy of Michael Halassa.The thalamic reticular nucleus (TRN) surrounds the thalamus (pictured in red, with a switchboard in the background).

Findings help explain how the brain pays attention to what’s important and how neural circuits may be ‘broken’ in attention-deficit disorders. Researchers at NYU Langone Medical Center say they have added to evidence that the thalamic reticular nucleus or TRN in the central brain, is likely responsible for the ability to routinely and seamlessly multitask.

The process, they suggest, is done by individual TRN neurons that act like a “switchboard,” continuously filtering sensory information and shifting more or less attention onto one sense – like sight – while relatively blocking out distracting information from o...