aging tagged posts

Beneficial Effects of Exercise Change with Age

Exercise-induced ROS activates Nrf2, which then translocates into the nucleus to increase the expression of antioxidant enzymes. Antioxidant response element (ARE), carbon monoxide (CO), Glutathione peroxidase (GPx), Glutathione S-transferase (GST), Heme oxygenase-1 (HO-1), Kelch-like ECH-associated protein 1 (Keap1), NAD(P)H quinone oxidoreductase-1 (NQO-1), and nuclear factor erythroid 2-related factor 2 (Nrf2).

Exercise-induced ROS activates Nrf2, which then translocates into the nucleus to increase the expression of antioxidant enzymes. Antioxidant response element (ARE), carbon monoxide (CO), Glutathione peroxidase (GPx), Glutathione S-transferase (GST), Heme oxygenase-1 (HO-1), Kelch-like ECH-associated protein 1 (Keap1), NAD(P)H quinone oxidoreductase-1 (NQO-1), and nuclear factor erythroid 2-related factor 2 (Nrf2).

If you’re an older adult, a 30 min workout may not be as effective, even at the cellular level, as it was when you were younger. According to a new study, age may play a significant role in a cell’s ability to respond to that activity. In the study, a group of men 18 to 30 yo were tested against a group of older men 55 years and older...

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Exercise Keeps Muscles, and You, Young

“These are individuals in their 80s and 90s who actively compete in world masters track and field championships. We have seven world champions. These individuals are the crème de la crème of aging.”

“These are individuals in their 80s and 90s who actively compete in world masters track and field championships. We have seven world champions. These individuals are the crème de la crème of aging.”

A Uni of Guelph professor has uncovered the “secret” to staying strong as we age – superb fitness. Geoff Power found elderly people who were elite athletes in their youth or later in life – and who still compete as masters athletes – have much healthier muscles at the cellular level compared to those of non-athletes.

The study compared world-class track and field athletes in their 80s with people of the same age who are living independently. There have been few such studies of aging and muscle weakening in masters athletes in this age group...

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Link made between Genetics, Aging

Rob Pazdro, left, and Yang Zhou led a study looking at a new pathway by which genetics regulates aging and disease. Credit: Cal Powell/University of Georgia

Rob Pazdro, left, and Yang Zhou led a study looking at a new pathway by which genetics regulates aging and disease. Credit: Cal Powell/University of Georgia

Uni of Georgia scientists have shown a hormone instrumental in the aging process is under genetic control, introducing a new pathway by which genetics regulates aging and disease. Previous studies have found that blood levels of this hormone, growth differentiation factor 11, decrease over time. Restoration of GDF11 reverses cardiovascular aging in old mice and leads to muscle and brain rejuvenation, a discovery that was listed as one of the top 10 breakthroughs in science in 2014.

Scientists in the UGA College of Family and Consumer Sciences have now discovered that levels of this hormone are determined by genetics, representing ano...

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Experiments have Conclusively Proven for the 1st time Mitochondria are Major Triggers of Cell Aging

This image shows Dr. Joao Passos and Dr. Clara Correia-Melo in the lab. Credit: Newcastle University

This image shows Dr. Joao Passos and Dr. Clara Correia-Melo in the lab. Credit: Newcastle University

This brings scientists a step closer to developing therapies to counteract the aging of cells, by targeting mitochondria. In a study, published today in the EMBO Journal and led by Dr João Passos at Newcastle University, they found that when mitochondria were eliminated from aging cells they became much more similar to younger cells. As we grow old, cells in our bodies accumulate different types of damage and have increased inflammation, factors which are thought to contribute to the aging process.

The team carried out a series of genetic experiments involving human cells grown in the laboratory and succeeded in eliminating the majority, if not all, the mitochondria from aging cells...

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