AI tagged posts

Creating AI that’s Fair and Accurate: Framework moves Beyond Binary Decisions to offer a more Nuanced Approach

AI that's fair and accurate
Credit: MIT CSAIL

Two of the trickiest qualities to balance in the world of machine learning are fairness and accuracy. Algorithms optimized for accuracy may unintentionally perpetuate bias against specific groups, while those prioritizing fairness may compromise accuracy by misclassifying some data points.

With this challenge in mind, a team from CSAIL has taken the lead in devising a framework that enables a more nuanced approach to balancing these qualities.

Instead of forcing a binary decision in labeling all data points as “good” or “bad,” their framework uses their Reject Option Classification (ROC) algorithm which assigns a third category of “rejected samples,” allowing it to identify instances where the model might be less certain or where predictions could potentially le...

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A “Chemical ChatGPT” for New Medications

Three-dimensional structures of two target proteins,
Three-dimensional structures of two target proteins, – histone deacetylase 6 (blue) and tyrosine-protein kinase JAK2 (red), together with a selective inhibitor of each enzyme. The dual inhibitor in the center is active against both targets. The prediction of compounds with predefined dual-target activity is the task of the chemical language model.© Figure: Sanjana Srinivasan & Jürgen Bajorath

Researchers from the University of Bonn have trained an AI process to predict potential active ingredients with special properties. Therefore, they derived a chemical language model — a kind of ChatGPT for molecules. Following a training phase, the AI was able to exactly reproduce the chemical structures of compounds with known dual-target activity that may be particularly effective medications...

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Researchers use AI to find Non-Opioid Pain Relief Options

AI
Credit: Google DeepMind from Pexels

An estimated one in five Americans live with chronic pain and current treatment options leave much to be desired. Feixiong Cheng, Ph.D., Director of Cleveland Clinic’s Genome Center, and IBM are using artificial intelligence (AI) for drug discovery in advanced pain management. The team’s deep-learning framework identified multiple gut microbiome-derived metabolites and FDA-approved drugs that can be repurposed to select non-addictive, non-opioid options to treat chronic pain.

The findings, published in Cell Press, represent one of many ways the organizations’ Discovery Accelerator partnership is helping to advance research in healthcare and life sciences.

Treating chronic pain with opioids is still a challenge due to the risk of severe side eff...

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AI helps Distinguish Dark Matter from Cosmic Noise

An AI-powered tool can distinguish dark matter’s elusive effects from other cosmic phenomena, which could bring us closer to unlocking the secrets of dark matter.

Dark matter is the invisible force holding the universe together – or so we think. It makes up around 85% of all matter and around 27% of the universe’s contents, but since we can’t see it directly, we have to study its gravitational effects on galaxies and other cosmic structures. Despite decades of research, the true nature of dark matter remains one of science’s most elusive questions.

According to a leading theory, dark matter might be a type of particle that barely interacts with anything else, except through gravity...

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