Schematic representation of the contribution of soluble ADAM33 (sADAM33) as a local tissue susceptibility gene in asthma pathobiology.
A potential novel way of preventing asthma at the origin of the disease has been found, a finding that could challenge the current understanding of the condition. Insight, analysed the impact of the gene ADAM33, which is associated with the development of asthma. ADAM33 makes an enzyme, which is attached to cells in the airway muscles. When the enzyme loses its anchor to the cell surface, it is prone to going rogue around the lung causing poorer lung function in people who have asthma.
The studies in human tissue samples and mice, led by A/Prof Hans Michel Haitchi suggests that if you inhibit ADAM33 or prevent it from going rouge, the features of asthma – a...
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