alcohol consumption tagged posts

Alcohol consumption increases the risks of over 60 diseases in Chinese men, including many diseases not previously linked to alcohol, according to a new study by researchers from Oxford Population Health and Peking University, published in Nature Medicine.

Alcohol consumption is estimated to be responsible for about 3 million deaths worldwide each year, and it is increasing in many low- and middle-income countries such as China. The harmful effects of heavy drinking for certain diseases (such as liver cirrhosis, stroke and several types of cancer) are well known, but very few studies have systematically assessed the impact of alcohol use on an extensive range of diseases within the same population.

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Highlights
•Mutation clusters in cancer genomes provide fingerprints of mutagenic mechanisms
•Error-free mismatch repair lowers the mutation rate in H3K36me3-marked active genes
•Error-prone repair using POLH also targets H3K36me3, contributing driver mutations
•UV and alcohol increase error-prone repair, targeting mutations toward active genes

Sunlight, alcohol consumption increase the rate at which this happens, resulting in more mutations in the most important parts of our genomes. Cancer is mostly caused by changes in the DNA of our cells that occur during our lifetime rather than those that we inherit from our parents. Identifying the causes of these ‘mutations’ is a difficult challenge because many processes can result in an identical DNA sequence change in a genome...