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How Allergens Trigger Itching: Finding points to new targets for allergy drug development

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Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to AllergensImmunity, 2020; DOI: 10.1016/j.immuni.2020.10.001

A key step in the immune system’s response to allergens has been uncovered by researchers at Massachusetts General Hospital (MGH). They have shown that a neuropeptide called Substance P is released by certain neurons in the skin when they detect allergens, and that this substance is essential in the development of allergen-induced immune responses. This research could lead to the development of new and better methods to treat and prevent allergies.

How allergens are detected by the immune system had not been known...

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