Alzheimer’s disease tagged posts

Researchers at Baylor College of Medicine, the University of Cambridge in the U.K. and collaborating institutions have shown that serotonin 2C receptor in the brain regulates memory in people and animal models. The findings, published in the journal Science Advances, not only provide new insights into the factors involved in healthy memory but also in conditions associated with memory loss, like Alzheimer’s disease, and suggest novel avenues for treatment.

“Serotonin, a compound produced by neurons in the midbrain, acts as a neurotransmitter, passing messages between brain cells,” said co-corresponding author Dr. Yong Xu, professor of pediatrics—nutrition and associate director for basic sciences at the USDA/ARS Children’s Nutrition Research Center at Baylor.

“Serotonin-produc...

Proteins are nature’s polymers, governing biological processes at every level. A new study presents artificial proteins made using modern, precision polymers to intervene and alter natural processes towards a new way of developing therapeutics.

Researchers led by Northwestern University and the University of Wisconsin-Madison have introduced a pioneering approach aimed at combating neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease and Amyotrophic lateral scleros...

Medical researchers have used a 3D human neural cell culture model to show that the exercise-induced muscle hormone, irisin, reduces the level of amyloid beta deposits associated with Alzheimer’s disease.

Researchers who previously developed the first 3D human cell culture models of Alzheimer’s disease (AD) that displays two major hallmarks of the condition — the generation of amyloid beta deposits followed by tau tangles — have now used their model to investigate whether the exercise-induced muscle hormone irisin affects amyloid beta pathology.

As reported in the journal Neuron, the Massachusetts General Hospital (MGH)-led team has uncovered promising results suggesting that irisin-b...

Immune cell discovery a new attack on Alzheimer’s, neurological disorders. Combating Alzheimer’s and other neurodegenerative diseases by inserting healthy new immune cells into the brain has taken a leap toward reality. Neuroscientists at the University of California, Irvine and the University of Pennsylvania have found a way to safely thwart the brain’s resistance to them, vaulting a key hurdle in the quest.

Their discovery about brain cells called microglia heralds myriad possibilities for treating and even preventing neurodegenerative disorders. The team’s paper appears in the Journal of Experimental Medicine.

When microglia are healthy, ...