Do more with one link - claim and personalize your FREE link today! Effortlessly schedule, video meet, message chat, network, share materials, e-sign, etc – all in one spot. Collaborate, Nurture connections, Improve client services, Expedite deal closures, and more. 💼 Join FREE!!

Recent Comments

    Alzheimer’s disease tagged posts

    Researchers identify ‘Neurostatin’ that may Reduce the Risk of Alzheimer’s disease

    February 14, 2016, Categories  Biology/Biotechnology, Health/Medical

    Schematic illustration of the drug discovery strategy described in this work. The strategy consists of four steps: (1) A fragment-based approach that allows the identification of small molecules that interact with the aggregation-prone system, here Aβ42, including FDA-approved molecules for drug repurposing. (2) An in vitro kinetic analysis that identifies the specific molecular steps in the Aβ42 aggregation mechanism responsible for the generation of toxic species. (3) A further kinetic analysis to determine the mechanism of inhibition associated with the molecules identified in step 1. (4) An evaluation of the effects of these molecules on the formation of toxic species in vivo. In particular, the inhibition of primary nucleation is predicted to delay the aggregation without affecting the total number of oligomers generated by the aggregation process, whereas inhibiting elongation or secondary nucleation is predicted either to increase or to decrease the number of toxic oligomers, respectively (see text).

    Schematic illustration of the drug discovery strategy described in this work. The strategy consists of four steps: (1) A fragment-based approach that allows the identification of small molecules that interact with the aggregation-prone system, here Aβ42, including FDA-approved molecules for drug repurposing. (2) An in vitro kinetic analysis that identifies the specific molecular steps in the Aβ42 aggregation mechanism responsible for the generation of toxic species. (3) A further kinetic analysis to determine the mechanism of inhibition associated with the molecules identified in step 1. (4) An evaluation of the effects of these molecules on the formation of toxic species in vivo...

    Read More

    Lipid-based diets effectively Combat Alzheimer’s disease in mouse model

    February 11, 2016, Categories  Biology/Biotechnology, Health/Medical

    Researchers have devised several lipid-based diets aimed at slowing down progression and relieving symptoms of Alzheimer's disease. Credit: Janickova et al, Bentham Science Publishers

    Researchers have devised several lipid-based diets aimed at slowing down progression and relieving symptoms of Alzheimer’s disease. Credit: Janickova et al, Bentham Science Publishers

    Numerous epidemiological studies have revealed profitable effects of dietary intake of especially fish oil on cognitive decline during aging and dementia. One of the invariable pathologies in AD is degeneration of cholinergic synapses in brain cortex and hippocampus. Current pharmacological interventions are limited to a few drugs that alleviate symptoms but do not slow down the underlying disease processes eg inhibitors of cholinesterases, enzymes that degrade the neurotransmitter acetylcholine, or memantine, a modulator of glutamate neurotransmission.

    Within the EU-funded project LipiDiDiet (FP7-211696, the...

    Read More

    Mesh-like Scaffold is Disordered in Alzheimer’s-affected cells

    February 6, 2016, Categories  Biology/Biotechnology, Health/Medical

    A cell nucleus from a normal, healthy brain is shown at left. The lamin nucleoskeleton forms the perimeter around the nucleus. By contrast, tunnel-like anomalies are evident in the nucleus of the Alzheimer's disease-affected cell shown at right. This image is from the laboratory of Bess Frost, Ph.D., of the School of Medicine and Barshop Institute for Longevity and Aging Studies at The University of Texas Health Science Center at San Antonio. Credit: Laboratory of Bess Frost, Ph.D./UT Health Science Center San Antonio

    A cell nucleus from a normal, healthy brain is shown at left. The lamin nucleoskeleton forms the perimeter around the nucleus. By contrast, tunnel-like anomalies are evident in the nucleus of the Alzheimer’s disease-affected cell shown at right. This image is from the laboratory of Bess Frost, Ph.D., of the School of Medicine and Barshop Institute for Longevity and Aging Studies at The University of Texas Health Science Center at San Antonio. Credit: Laboratory of Bess Frost, Ph.D./UT Health Science Center San Antonio

    A new finding offers a insight into one of the earliest biological events of Alzheimer’s disease and is expected to open new avenues of study. Neuronal cell death in Alzheimer’s disease is linked to disruption of a lamin nucleoskeleton that surrounds the nucleus of the cells...

    Read More

    Insulin-like Growth Factor linked to Hippocampal Hyperactivity in Alzheimer’s disease

    February 1, 2016, Categories  Biology/Biotechnology, Health/Medical

    IGF-1R Regulates Short-Term Synaptic Facilitation under Physiological and AD-Related Conditions

    IGF-1R Regulates Short-Term Synaptic Facilitation under Physiological and AD-Related Conditions

    Researchers find IGF-1 receptor, “master” lifespan regulator, plays critically important role regulating the transfer of information within neural circuits. They hope their findings can be used to indicate a new direction for therapy used to treat patients in the early stages of Alzheimer’s disease.

    The research reveals IGF-1R as a differential regulator of 2 different modes of transmission – spontaneous and evoked – in hippocampal circuits of the brain. “We know that IGF-1R signaling controls growth, development and lifespan, but its role in AD has remained controversial,” said Dr. Slutsky...

    Read More