 The healthy ageing RNA signature in healthy human brain tissue and blood of AD patients and controls. There was robust regulation of the healthy ageing RNA signature in human brain with healthy ageing and between control subjects and subjects with AD or MCI. The healthy ageing RNA signature in healthy human brain tissue and blood of AD patients and controls. There was robust regulation of the healthy ageing RNA signature in human brain with healthy ageing and between control subjects and subjects with AD or MCI. a The healthy ageing RNA signature was studied across brain regions in healthy individuals using BrainEac.org gene-chip resource [GEO:GSE60862]... |
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Alzheimer’s disease tagged posts
Early Warning RNA Signature for Alzheimer’s
September 7, 2015,
Biology/Biotechnology, Health/Medical
Degenerating Neurons respond to Gene Therapy for Alzheimer’s disease
August 29, 2015,
Biology/Biotechnology, Health/Medical
Alzheimer Disease Pathology and Site of Gene Delivery in a Patient 7 Years After Gene Transfer Credit: http://archneur.jamanetwork.com/article.aspx?articleid=2427383
The affected neurons displayed heightened growth, axonal sprouting and activation of functional markers after nerve growth factor (NGF) was injected into their brains.The findings are derived from postmortem analyses of 10 patients who participated in phase I clinical trials launched in 2001 to assess whether injected NGF – a protein essential to cellular growth, maintenance and survival – might safely slow or prevent neuronal degeneration in patients with AD.
Cholinergic Neuronal Hypertrophy and Sprouting Credit: http://archneur.jamanetwork.com/article.aspx?articleid=2427383
Administering NGF directly into the brain – a fir...
Read MoreAlzheimer’s disease thought to be Accelerated by an Abnormal Build-up of Fatty Acids in the Brain
August 27, 2015,
Biology/Biotechnology, Health/Medical
Highlights •Early neural stem cell NSC impairment in 3xTg-AD mice correlates with SVZ subventricular zone niche lipid accumulations •Similar lipid accumulations are found in the SVZ in postmortem human AD brains •Accumulating SVZ lipids are locally generated, oleic acid-enriched triglycerides •Inhibiting oleic acid signaling or synthesis rescues NSC defects in 3xTg-AD mice Credit: Fernandes et al. Aberrant Lipid Metabolism in the Forebrain Niche Suppresses Adult Neural Stem Cell Proliferation in an Animal Model of Alzheimer’s Disease. Cell Stem Cell, 27 August 2015 DOI: 10.1016/j.stem.2015.08.001
For the 1st time since the disease was described 109 years ago, researchers have discovered accumulations of fat droplets/ lipids in the brain of patients who died from the disease and h...
Read MoreGlitter from silver lights up Alzheimer’s dark secrets
August 26, 2015,
Biology/Biotechnology, Health/Medical
The picture shows toxic Alzheimer’s amyloid beta molecules landing on a fake cell membrane, wrapped around a silver nanoparticle. A laser, with help from the silver particle, lights up the molecule to reveal its structure. Credit: Copyright Debanjan Bhowmik; Credit to Debanjan Bhowmik, TIFR, Mumbai
The elusive toxic form of the Alzheimer’s molecule has now been observed, during its attempt to bore into the outer covering of a cell decoy, using a new method involving laser light and fat-coated silver nanoparticles.
“Everybody wants to make the key to solve Alzheimer’s Disease, but we don’t know what the lock looks like. We now have a glimpse of something which could be the lock...
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