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    Alzheimer’s disease tagged posts

    First observation of the Early Link between Proteins linked to Alzheimer’s disease

    January 27, 2021, Categories  Biology/Biotechnology, Health/Medical

    State-of-the-art automatic brainstem segmentation methods were used to extract tau burden in its first aggregation site, that is, in the brainstem monoaminergic grey matter (bmGM). Beta-amyloid (Aβ) burden was extracted in the earliest cortical aggregation regions, i.e. in the bilateral medial superior frontal, inferior temporal, and fusiform areas.
    State-of-the-art automatic brainstem segmentation methods were used to extract tau burden in its first aggregation site, that is, in the brainstem monoaminergic grey matter (bmGM). Beta-amyloid (Aβ) burden was extracted in the earliest cortical aggregation regions, i.e. in the bilateral medial superior frontal, inferior temporal, and fusiform areas.

    Study conducted by researchers from the GIGA CRC In vivo Imaging laboratory at ULiège demonstrates, for the first time in humans, how the first deposits of tau proteins in the brainstem are associated with neurophysiological processes specific to the early stages of Alzheimer’s disease development.

    During the pre-clinical stages of Alzheimer’s disease, i.e...

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    New Blood Test shows great promise in the diagnosis of Alzheimer’s disease

    July 31, 2020, Categories  Biology/Biotechnology, Health/Medical

    Plasma P-tau217 Concentrations in the Neuropathology Cohort

    A new blood test demonstrated remarkable promise in discriminating between persons with and without Alzheimer’s disease and in persons at known genetic risk may be able to detect the disease as early as 20 years before the onset of cognitive impairment, according to a large international study published today in the Journal of the American Medical Association (JAMA) and simultaneously presented at the Alzheimer’s Association International Conference.

    For many years, the diagnosis of Alzheimer’s has been based on the characterization of amyloid plaques and tau tangles in the brain, typically after a person dies...

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    Nanodevices for the Brain could thwart formation of Alzheimer’s Plaques

    May 2, 2020, Categories  Biology/Biotechnology, Health/Medical

    Scanning Electron Microscopy (SEM) images of the porous silica nanodevices. The exposed amount of surface area provides high opportunity to attach the peptide-attracting antibody fragments. (Image by Center for Nanoscale Materials, Argonne National Laboratory.)
    Scanning Electron Microscopy (SEM) images of the porous silica nanodevices. The exposed amount of surface area provides high opportunity to attach the peptide-attracting antibody fragments. (Image by Center for Nanoscale Materials, Argonne National Laboratory.)

    Researchers designed a nanodevice with the potential to prevent peptides from forming dangerous plaques in the brain in order to halt development of Alzheimer’s disease. Alzheimer’s disease is the sixth leading cause of death in the United States, affecting one in 10 people over the age of 65. Scientists are engineering nanodevices to disrupt processes in the brain that lead to the disease.

    People who are affected by Alzheimer’s disease have a specific type of plaque, made of self-assembled molecules called β-amyloid (Aβ) pep...

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    Gene Variant Staves off Alzheimer’s in some people

    April 15, 2020, Categories  Biology/Biotechnology, Health/Medical

    Michael Greicius is the senior author of a study whose findings may help drug developers better identify treatments for Alzheimer’s disease.
    Norbert von der Groeben

    A substantial fraction of the estimated 15% of Americans carrying the high-risk gene variant of Alzheimer’s are protected to some degree from Alzheimer’s disease by a variant of the other gene. (A gene will often come in a variety of versions, or variants, that can produce different traits.)

    The findings also may help drug developers better identify clinical trial participants and treatments for what, despite billions of dollars spent in pursuit of effective therapies, remains a disease without a cure.

    About 5 million Americans – including roughly 1 in 10 people age 65 or older and one-third of those age 85 or older – have sy...

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