Alzheimer’s disease tagged posts

Images that predate the formation of toxic clumps of beta-amyloid, the protein believed to be at the root of Alzheimer’s disease, have now been captured by researchers. Credit: Illustration: Per Uvdal

MAX IV synchrotron in Lund, Sweden – the strongest of its kind in the world – has been used to produce images that predate the formation of toxic clumps of beta-amyloid, the protein believed to be at the root of Alzheimer’s disease. The unique images appear to contradict a previously unchallenged consensus. Instead of attempting to eliminate beta-amyloid plaques, the researchers now suggest stabilizing the protein.

It is a long-held belief in the scientific community that the beta-amyloid plaques appear almost instantaneously. Hence the term “popcorn plaques...

1. Schematic model of miR-29 action in brain aging. During aging an accumulation of iron in neurons occurs. This induces expression of miR-29 that in turn represses expression of IRP-2 thereby limiting iron uptake. This mechanism counteracts aging-related damages. MiR-29 may also counteract effects aging-related phenotypes by additional mechanisms, for example modulation of pro-apoptotic BCL-2 family members
2. MiR-29 is up-regulated with age in neurons. a Genomic organization of miR-29 family in N. furzeri.

The older we get, our brain ages. Cognitive abilities decline and the risk of developing neurodegenerative diseases like dementia, Alzheimer’s and Parkinson’s disease or having a stroke steadily increases...

Vitamin A deficiency increased the production of plaques in the brains of mice.

Vitamin A deficiency could ‘program’ brain tissue. Biochemical reactions that cause Alzheimer’s disease could begin in the womb or just after birth if the fetus or newborn does not get enough vitamin A, according to new research from the University of British Columbia. These new findings, based on studies of genetically-engineered mice, also demonstrate that Vit A supplement given to newborns with low levels of vitamin A could be effective in slowing the degenerative brain disease.

“Our study clearly shows that marginal deficiency of vitamin A, even as early as in pregnancy, has a detrimental effect on brain development and has long-lasting effect that may facilitate Alzheimer’s disease in later life,” said Dr...

This is a grid cell from the entorhinal cortex (EC) of the mouse brain, firing repeatedly and uniformly in a grid-like pattern. When a mouse moves through its environment, grid cells are activated, with each cell representing a specific location. This creates a triangular coordinate system that allows for spatial navigation. Several grid cells create a triangular coordinate system that allows for spatial navigation. The accumulation of tau protein in the brain of a mouse model of Alzheimer’s disease was shown to disrupt the function of grid cells, causing problems with navigation. The findings explains why Alzheimer’s patients tend to wander and get lost. Credit: Lab of Karen Duff, PhD, Columbia University Medical Center

Finding may explain why many Alzheimer’s disease patients wander...