Alzheimer’s tagged posts

Images: 1. RHEB, Ras homolog enriched in brain  2. BACE1

TSRI Florida scientists have made an important discovery toward the development of drugs to treat age-related memory loss in diseases like Alzheimer’s. They found that reduced levels of a protein called Rheb result in spontaneous symptoms of memory loss in animal models and are linked to increased levels of another protein known to be elevated in the brains of Alzheimer’s disease patients. Subramaniam’s group investigated the link between Rheb and an important enzyme called BACE1, which is elevated in older adults and people with Alzheimer’s disease.

“We know that Rheb regulates BACE1, which is a major drug target in Alzheimer’s disease,” Subramaniam said...

Highlights •Mitochondrial dysfunction and defective mitophagy shown in A-T animal models •A-T laboratory animal models exhibit NAD+ depletion and impaired SIRT1 activity •NAD+ replenishment improves lifespan and healthspan in ATM− worms and mice •NAD+ ameliorates A-T phenotypes through upregulation of mitophagy and DNA repair

The coenzyme NAD+ plays a main role in aging processes. In mice and roundworm adding the substance can both extend life and postpone the onset of aging processes. New research conducted at the Center for Healthy Aging and the American National Institute of Health shows that this new knowledge will eventually be able to help patients with Alzheimer’s and Parkinson’s disease.

An international team of researchers from the Center for Healthy Aging at the Univers...

Acetylcholine receptors, also known as nicotinic receptors

Several scientific studies have indicated that nicotine may be beneficial for memory function. Scientists set out to shed further light on the properties attributed to nicotine – which is known to have an adverse effect on health – by determining the precise structure of the nicotinic receptors in the hippocampus region of the brain. Using mouse models for Alzheimer’s disease, they identified the β2 subunit of the nicotinic receptor as a target that, if blocked, prevents the memory loss associated with Alzheimer’s.

Alzheimer’s disease is characterized by two types of lesion: amyloid plaques and neurofibrillary degeneration...

Dreaming. REM sleep is understood to be a critical component of sleep in all mammals, including humans. Credit: © Anton Maltsev / Fotolia

For decades, scientists have fiercely debated whether rapid eye movement (REM) sleep – the phase where dreams appear – is directly involved in memory formation. Now researchers provide evidence that REM sleep does, indeed, play this role – at least in mice. “We already knew that newly acquired information is stored into different types of memories, spatial or emotional, before being consolidated or integrated,” says Sylvain Williams, a researcher and professor of psychiatry at McGill.

“How the brain performs this process has remained unclear – until now...