Alzheimer’s tagged posts

Previous experiment (a) When Dnmt3a2 is overexpressed in aged mice, it improves memory formation. (b) Conversely, when Dnmt3a2 is artificially reduced in young mice by shRNA-mediated knockdown, this is sufficient to disrupt memory formation. These results demonstrate the requirement for Dnmt3a2 in hippocampus-dependent memory formation.

Research findings could lead to new treatment for anxiety disorders including PTSD. Mouse experiments showed that the Dnmt3a2 protein can boost memory performance in the animals. Because this protein also affects fear memory and the ability to erase bad memories, the researchers hope these findings can be used to develop new treatments for post-traumatic stress disorder and other forms of anxiety.

In an earlier study, the Heidelberg scientists learned that ...

RGFP966 is an HDAC3 inhibitor

Clues to keeping brain cells alive in those with Alzheimer’s. A drug now being used to treat cancer might make it easier to learn a language, sharpen memory and help those with dementia and Alzheimer’s disease by rewiring the brain and keeping neurons alive. New research found that a drug – RGFP966 – administered to rats made them more attuned to what they were hearing, able to retain and remember more information, and develop new connections that allowed these memories to be transmitted between brain cells.”This drug could rescue the ability to make new memories that are rich in detail and content, even in the worst case scenarios.”

What happens with dementias such as Alzheimer’s is that brain cells shrink and die because the synapses that transfer informatio...