Alzheime’s disease tagged posts

In some people, the brain protein tau collects into toxic tangles that damage brain cells and contribute to diseases such as Alzheimer’s. Researchers at Washington University School of Medicine in St. Louis have found a drug that can lower tau levels and prevent some neurological damage. In neurons that contain the drug (above, in red) there are no tau tangles (in green). Credit: Sarah DeVos

Appears to reverse some neurological harm. Under ordinary circumstances, the protein tau contributes to the normal, healthy functioning of brain neurons. In some people, though, it collects into toxic tangles that damage brain cells. Such tangles are a hallmark of Alzheimer’s and other neurodegenerative diseases. But researchers at Washington University School of Medicine in St...

Marijuana appears to hamper blood flow to the brain, which theoretically could affect your memory and ability to reason, a new study suggests.

Marijuana appears to hamper blood flow to the brain, which theoretically could affect your memory and ability to reason, a new study suggests. Brain scans of nearly 1,000 past and present marijuana users revealed abnormally low blood flow throughout their brains, compared with a smaller control group of 92 people who’d never used pot. “The differences were astonishing,” said Dr. Daniel Amen, a psychiatrist and founder of the U.S.-based Amen Clinics. “Virtually every area of the brain we measured was lower in blood flow and activity in the marijuana smokers than in the healthy group.”

Blood flow was lowest in the hippocampus of marijuana users, which...

The Salk team expanded upon their previous development of a drug candidate J147, which takes a different tack by targeting Alzheimer’s major risk factor—old age. In the new work, the team showed that the drug candidate worked well in a mouse model of aging not typically used in Alzheimer’s research. When these mice were treated with J147, they had better memory and cognition, healthier blood vessels in the brain and other improved physiological features.

“Initially, the impetus was to test this drug in a novel animal model that was more similar to 99% of Alzheimer’s cases,” says Prof Antonio Currais. “We did not predict we’d see this sort of anti-aging effect, but J147 made old mice look like they were young, based upon a number of physiological parameters.”

Alzheimer’s is the 3rd ...