Alzheime’s disease tagged posts

Five ways microplastics may harm your brain

Five ways microplastics may harm your brain
MP’s ability to cross the BBB through phagocytosis and BBB damage Credit: Molecular and Cellular Biochemistry (2025). DOI: 10.1007/s11010-025-05428-3

Microplastics could be fueling neurodegenerative diseases like Alzheimer’s and Parkinson’s, with a new study highlighting five ways microplastics can trigger inflammation and damage in the brain.

More than 57 million people live with dementia, and cases of Alzheimer’s and Parkinson’s are projected to rise sharply. The possibility that microplastics could aggravate or accelerate these brain diseases is a major public health concern.

Pharmaceutical scientist Associate Professor Kamal Dua, from the University of Technology Sydney, said it is estimated that adults are consuming 250 grams of microplastics every year—enough to cover a...

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NAD⁺ restores memory in Alzheimer’s disease models by correcting RNA errors

NAD⁺ restores memory in Alzheimer's' disease models by correcting RNA errors
NR induces transcription of genes involved in axon development, oxygen metabolism, mitochondrion localization, and autophagy in tauopathy mice. GO terms enriched in each of the eight classes of clusters in (A); each circular bar graph represents one cluster or class of clusters, and bar length correlates with the number of DEGs represented. GO terms shown in red font relate to mRNA. Clusters 4 and 5 are similar and are grouped together. Class 1 includes clusters 1, 2, and 6 marked with red. Class 2 includes clusters 4 and 5 marked with orange. Class 3 includes cluster 8 marked with yellow. GTPase, guanosine triphosphatase; NAD(P)H, reduced form of NAD phosphate; IRES, internal ribosomal entry site; GTP, guanosine 5′-triphosphate; MHC, major histocompatibility complex. Credit: Science A...
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Simple insulin resistance test may also predict cognitive decline in Alzheimer’s patients

blood test
Credit: Artem Podrez from Pexels

Insulin resistance detected by routine triglyceride-glucose (TyG) index can flag people with early Alzheimer’s who are four times more likely to present rapid cognitive decline, according to new research presented at the European Academy of Neurology (EAN) Congress 2025.

Neurologists at the University of Brescia reviewed records of 315 non-diabetic patients with cognitive deficits, including 200 with biologically confirmed Alzheimer’s disease. All subjects underwent an assessment of insulin resistance using the TyG index and a clinical follow-up of three years.

The work is published in the journal Alzheimer’s & Dementia.

When patients were divided according to the TyG index, those in the highest third of the Mild Cognitive Impairment AD subgrou...

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Biking may promote healthy brain aging

Biking might promote healthy brain aging
Want to reduce your risk of dementia and Alzheimer’s disease?

Get on your bike and ride, a new study recommends.
Biking regularly for transportation appears to lower risk of dementia by 19% and Alzheimer’s by 22%, according to results published June 9 in JAMA Network Open.

The results also suggest that cycling might even help increase the size of a brain region important for memory, researchers noted.

“Cycling is a moderate- to high-intensity workout, and also requires balance,” said Dr. Liron Sinvani, director of geriatric services at Northwell Health in Manhasset, N.Y., who reviewed the findings. “It requires more complex brain functions than walking, which is why maybe it was a better reducer of dementia risk.”

“It’s not about just doing exercise and making that part of your...

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