AML tagged posts

A new study sheds light on the inherited components of 12 cancer types. The research confirmed the well-known heritability of breast and ovarian cancers and found a surprising inherited component to stomach cancer. In the graphic above, Lung 1 is lung squamous cell carcinoma, and Lung 2 is lung adenocarcinoma. Credit: Sara Dickherber

In a new analysis, researchers have shed light on these hereditary elements across 12 cancer types – showing a surprising inherited component to stomach cancer and providing some needed clarity on the consequences of certain types of mutations in well-known breast cancer susceptibility genes, BRCA1 and BRCA2...

Murphy et al. describe a novel pseudokinase architecture from human TRIB1 and characterize its substrate-recognition motif within the C/EBPα transcription factor. Combined with biophysical studies, this shows how Tribbles proteins eschew catalytic activity in favor of function as signaling scaffolds.

Protein Trib1 plays a vital role in controlling how and when other proteins are degraded, which is essential for managing protein levels in the cell. The finding could be used to develop new drugs to treat cancers such as leukaemia, caused by malfunctioning of the Trib1 protein.

Trib1 is part of the protein family Tribbles, which play diverse roles in cell signalling and development. Tribbles are named after the small, furry creatures from Star Trek that reproduce uncontrollably...