Blocking the activity of a fat-regulating enzyme in the muscles of mice leads to an increased capacity for endurance exercise, according to the results of a new study. Sugars and fats are the primary fuels that power every cell, tissue and organ. For most cells, sugar is the energy source of choice, but when nutrients are scarce, such as during starvation or extreme exertion, cells will switch to breaking down fats instead.
The mechanisms for how cells rewire their metabolism in response to changes in resource availability are not yet fully understood, but new research reveals a surprising consequence when one such mechanism is turned off: an increased capacity for endurance (exercise.
In a study published in the Aug...
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