amylin tagged posts

Oleuropein promotes glucose-stimulated insulin secretion (GSIS) in β-cells. The effect is dose-dependent and stimulates the ERK/MAPK signaling pathway. We further demonstrated that oleuropein inhibits the cytotoxicity induced by amylin amyloids, a hallmark feature of type 2 diabetes.

A Virginia Tech team discovered that oleuropein from olive leaves helps the body secrete more insulin. The same compound also detoxifies another signaling molecule called amylin that over-produces and forms harmful aggregates in type 2 diabetes. In these two distinct ways, oleuropein helps prevent the onset of disease.

“Our work provides new mechanistic insights into the long-standing question of why olive products can be anti-diabetic,” said Bin Xu, assistant professor of biochemistry in the College of Agric...

Scientists found evidence of the metabolism-regulating protein amylin, shown in red, present in multiple regions throughout a brain area called the hypothalamus. Experiments suggest amylin produced by hypothalamic neurons helps reduce food consumption together with leptin. Credit: Laboratory of Molecular Genetics at The Rockefeller University/Cell Metabolism

Feeling hungry or full leads us to change how much we eat, but the molecular wiring of this process is not well understood. Scientists have identified a new player in this circuit called amylin, which contributes to reducing food consumption in mice. Prof. Jeffrey Friedman said; “Amylin caught our attention when we were profiling a set of neurons in the hypothalamus, a part of the brain known to be involved in feeding behavior...