Recent Comments

    androgen receptor tagged posts

    Hidden weakness makes prostate cancer self-destruct

    November 15, 2025, Categories  Biology/Biotechnology, Health/Medical

    Hidden Weak Spot May Help Defeat Prostate Cancer
    Scientists have identified a major weakness in prostate cancer cells by uncovering two enzymes, PDIA1 and PDIA5, that help the disease survive and resist treatment. Blocking these enzymes destabilizes the androgen receptor, the main driver of prostate cancer, causing tumor shrinkage and cell death. Credit: Shutterstock

    Scientists found a hidden flaw in prostate cancer’s survival system. Researchers have discovered that prostate cancer depends on two key enzymes, PDIA1 and PDIA5, to survive and resist therapy. When blocked, these enzymes cause the androgen receptor to collapse, killing cancer cells and enhancing the effects of drugs like enzalutamide. They also disrupt the cancer’s energy system, striking it on multiple fronts...

    Read More