•Hedgehog activation increases fibroblast heterogeneity and drives new cell states
•TGF-β pathway downstream of dermal Hedgehog mediates hair growth hyper-activation
•SCUBE3 is a new mesenchymal niche factor that activates hair growth
SCUBE3 identified as possible therapeutic treatment for androgenetic alopecia. University of California, Irvine-led researchers have discovered that a signaling molecule called SCUBE3 potently stimulates hair growth and may offer a therapeutic treatment for androgenetic alopecia, a common form of hair loss in both women and men.
The study, published online today in Developmental Cell, determined the precise mechanism by which the dermal papilla cells — speciali...
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