angiogenesis tagged posts

Blood vessel-on-a-chips show anti-cancer drug effects in human cells. Credit: 2018 YUKIKO MATSUNAGA, INSTITUTE OF INDUSTRIAL SCIENCE, THE UNIVERSITY OF TOKYO

Researchers at the Institute of Industrial Science (IIS), the University of Tokyo, CNRS and INSERM, report a new organ-on-a-chip technology for the study of blood vessel formation and drugs targeting this event. The technology recreates a human blood vessel and shows how new capillaries grow from a single vessel (parent vessel) in response to proper biochemical signaling cues. The technology can further be used to develop drugs targeting this growth as a therapeutic approach to treat cancer and blood-vessel-related diseases. The study can be read in EBioMedicine.

Angiogenesis describes a specific process of blood vessel formation from...

‘The adipokine leptin modulates adventitial pericyte functions by autocrine and paracrine signalling’ by Paolo Madeddu et al in Scientific Reports

A new discovery by University of Bristol scientists helps to explain how cells which surround blood vessels, pericytes, stimulate new blood vessels to grow with the hormone ‘leptin’ playing a key role. Leptin is produced by fat cells which helps to regulate energy balance in the body by inhibiting the appetite. This study, described in Scientific Reports, may have important implications for the treatment of heart attacks and also for cancer, the two main killers in the UK.

The growth of new blood vessels, ‘angiogenesis’, is an important process occurring both in health and disease...

found nestin labeling in cells of the vascular system, indicating blood vessels plasticity. Evidence of angiogenesis was seen throughout superior temporal cortex (primary auditory cortex), fusiform cortex (face recognition center), pons/midbrain and cerebellum in postmortem brains from ASD patients but not control brains. We found significant increases in both nestin and CD34, which are markers of angiogenesis localized to pericyte cells and endothelial cells, respectively. This labeling profile is indicative of splitting (intussusceptive), rather than sprouting, angiogenesis indicating the blood vessels are in constant flux rather than continually expanding.

Evidence of autism may be found in the composition and malfunction of the brain’s blood vessels, a team of scientists has found...

Migrating tumor cells produce a protein that aids them to set up home in bones, researchers show. If a tumor develops metastases, the chances of the patient’s survival will be severely diminished. Cancer cells that leave the primary tumor, travel through the body, and set up home in distal organs such as lungs and bones start to express cathepsin K ~ primarily found only in the bone and is secreted by osteoclasts.

Shastri and Christensen found in cell cultures, cathepsin K activated matrixmetalloprotease-9 (MMP-9), one of the key regulators of tumour development. MMP-9 can digest the bone matrix thereby allowing the arriving cancer cells to adapt and survive in their new environment...