Highlights •Cx43 expression and beige adipocyte gap junctions are increased during WAT beiging •Genetic disruption or pharmacological inhibition of Cx43 blunts WAT beiging •Overexpression of Cx43 promotes WAT beiging in the presence of a mild cold stimulus •Human beige or brown fat has higher Cx43 expression than white adipose tissue
When exposed to cold, clusters of cells within the body’s white fat become beige – a color change that reflects the creation of more energy-producing mitochondria, that enable cells to burn calories and give off heat...
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