Findings from the Garvan Institute of Medical Research reveal a new Australian drug that targets scar-like ‘fibrotic’ tissue within tumors shows promise for treating pancreatic ductal adenocarcinoma, one of the most aggressive forms of pancreatic cancer with a five-year survival rate of less than 10%.
The research in mouse models showed that when given in combination with chemotherapy, the drug PXS-5505 increased survival time by more than 35%, compared to chemotherapy treatment alone.
“The preclinical validation of this first-in-class anti-fibrotic drug marks a major milestone in our quest to overcome the significant challenges in treating pancreatic cancer and brings hope to patients and their families,” says Associate Professor Thomas Cox, head of the Matrix & Metastasis Lab ...
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