anti-inflammatory tagged posts

Allergy Study on ‘Dirty’ Mice Challenges the Hygiene Hypothesis

mice
Credit: CC0 Public Domain

The notion that some level of microbial exposure might reduce our risk of developing allergies has arisen over the last few decades and has been termed the hygiene hypothesis.

Now, an article published in Science Immunology by researchers from Karolinska Institutet challenges this hypothesis by showing that mice with high infectious exposures from birth have the same, if not an even greater ability to develop allergic immune responses than “clean” laboratory mice.

How microbes may prevent allergy has been a topic of great interest in recent times. Studies have suggested that certain infections might reduce the production of inflammatory antibodies to allergens and alter the behavior of T cells involved in allergies...

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Nanomedicine for Treating Inflammatory Bowel Disease

Schematic summary of the overall flow of the study, showing GlyNPs(BR) library synthesis and characterizations of the constructed GlyNP(BR) library.
Schematic summary of the overall flow of the study, showing GlyNPs(BR) library synthesis and characterizations of the constructed GlyNP(BR) library. 

Anti-inflammatory nanoparticles mimic glycocalyx. Chronic inflammatory bowel disease (IBD), such as Crohn’s disease and ulcerative colitis, is on the rise worldwide. The benefits of current medications are limited by problematic side effects. In the journal Angewandte Chemie, a South Korean research team has now introduced a new method of treatment. It is based on nanoparticles that mimic a special carbohydrate layer (glycocalyx) located on inflamed bowel cells, and which trigger anti-inflammatory effects in the diseased sites in the intestine.

Stomach cramps and severe diarrhea, often accompanied by significant weight loss, are some o...

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New Effective Treatment for Inflammatory Diseases found

New effective treatment for inflammatory diseases found - News ...
A. L. Cross et al. APPA (apocynin and paeonol) modulates pathological aspects of human neutrophil function, without supressing antimicrobial ability, and inhibits TNFα expression and signalling, Inflammopharmacology (2020). DOI: 10.1007/s10787-020-00715-5

New research conducted by the University of Liverpool and AKL Research and Development Ltd (AKLRD), published in Inflammopharmacology, highlights the potential benefits of a new drug treatment on the human body’s immune response in inflammation.

In a number of inflammatory conditions, such as osteoarthritis, rheumatoid arthritis and, more recently, COVID-19, major complications and extensive tissue damage can occur when the immune system becomes excessively and uncontrollably activated...

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Red Wine’s Resveratrol could help Mars Explorers stay strong

Terminal assessment of the muscles of the triceps surae, including soleus (A)and gastrocnemius wet mass (D), soleus (B) and gastrocnemius (E) average cross sectional area (CSA), and representative images of the soleus (C) and gastrocnemius (F) muscles stained with anti-collagen VI (red), anti-slow-skeletal myosin heavy chain (green), and DAPI (blue). N = 6 per group. The results are presented as mean ± SEM; the results of the post hoc tests following the ANOVA are indicated. *p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.001 vs. PWB100, respectively. #p < 0.05, ###p < 0.001, and #⁢#⁢#⁢#p < 0.0001 vs. PWB100 + RSV, respectively. $p < 0.05, $$p < 0.01, and $$$p < 0.001 vs. PWB40, respectively.

Nutraceuticals that preserve muscle in reduced gravity will support long-term space mis...

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