anti-PD-L1 tagged posts

Tumors Hijack the Cell Death Pathway to Live

From left: Drs. Yang-Xin Fu, Chuanhui Han, and Zhida Liu
From left: Drs. Yang-Xin Fu, Chuanhui Han, and Zhida Liu

Cancer cells avoid an immune system attack after radiation by commandeering a cell signaling pathway that helps dying cells avoid triggering an immune response, a new study led by UTSW scientists suggests. The findings, published in a recent issue of Nature Immunology, could eventually lead to new ways to augment existing treatments to fight this disease.

Researchers have long known that radiation – a mainstay of treatment protocols for many types of cancerous tumors – kills cancer cells in two different ways: The high-energy beams smite some cells directly, and these dead cells leak DNA that triggers a tumor-fighting immune response through proteins known as interferons (IFNs)...

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