antibody tagged posts

Scientists Identify Genes linked to High Production of Key Antibody

A rendering of a nanovial, a microscopic bowl-shaped container that the scientists used to capture individual cells and their secretions. The dark, donut-shaped object to the right is a cell; the blue-and-yellow objects to the left are secreted immunoglobulin G antibodies. (Image courtesy: Rene Chang/University of Washington)

A collaboration led by UCLA and the Seattle Children’s Research Institute has yielded new knowledge about the genes responsible for the production and release of immunoglobulin G, the most common type of antibody in the human body.

The finding has the potential to advance manufacturing of antibody-based therapies for diseases such as cancer and arthritis, as well as the development of medical treatments that rely on the production of antibodies.

Antibodies a...

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Slingshot to Shoot Drugs onto the site of an Infection

The molecular slingshot is composed of a synthetic DNA strand that can load a drug and then effectively act as the rubber band of the slingshot.

Ranallo, S. et al. “Antibody powered nucleic acid release using a DNA-based nanomachine.” Nature Communications, April 2017. doi: 10.1038/ncomms15150 (2017)

An international team from the University of Rome Tor Vergata and the University of Montreal has reported, in a paper published this week in Nature Communications, the design and synthesis of a nanoscale molecular slingshot made of DNA that is 20,000 times smaller than a human hair. This molecular slingshot could “shoot” and deliver drugs at precise locations in the human body once triggered by specific disease markers.

The molecular slingshot is only a few nanometres long and is composed of a synthetic DNA strand that can load a drug and then effectively act as the rubber band of the slingshot...

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