Anxiety tagged posts

Being Anxious Could be Good for You—in a Crisis

Modulation of threat encoding by individual anxiety. (a) Left panel: correlation (Pearson) between state anxiety and the difference of the encoding parameter estimates between THREAT+ and THREAT− conditions in temporal electrodes at 280 ms. Right panel: encoding parameter estimates in temporal electrodes split into high and low anxious individuals for both THREAT+ and THREAT− conditions at 280 ms. T+: THREAT+, T-: THREAT-. (b) Left, correlation (Pearson) between state anxiety and the encoding parameter estimates in motor lateralization signals for THREAT+ condition at 200 ms. Right, encoding parameter estimates in motor lateralization signals split into high and low anxious individuals for both THREAT+ and THREAT− conditions at 200 ms. ***: p<0.001, *p<0.05.  DOI: http://dx.doi.org/10.7554/eLife.10274.010  - See more at: http://elifesciences.org/content/4/e10274#sthash.lORur2Lf.dpuf

Modulation of threat encoding by individual anxiety. (a) Left panel: correlation (Pearson) between state anxiety and the difference of the encoding parameter estimates between THREAT+ and THREAT− conditions in temporal electrodes at 280 ms. Right panel: encoding parameter estimates in temporal electrodes split into high and low anxious individuals for both THREAT+ and THREAT− conditions at 280 ms. T+: THREAT+, T-: THREAT-. (b) Left, correlation (Pearson) between state anxiety and the encoding parameter estimates in motor lateralization signals for THREAT+ condition at 200 ms. Right, encoding parameter estimates in motor lateralization signals split into high and low anxious individuals for both THREAT+ and THREAT− conditions at 200 ms. ***: p<0.001, *p<0.05. DOI: http://dx.doi.org/10...

Read More

Yin and Yang of Serotonin Neurons in Mood Regulation

Serotonergic neurons in the dorsal raphe nucleus (DRN) and median raphe nucleus (MRN) of the brainstem differentially modulate emotional behavior. Credit: Columbia University Department of Psychiatry

Serotonergic neurons in the dorsal raphe nucleus (DRN) and median raphe nucleus (MRN) of the brainstem differentially modulate emotional behavior. Credit: Columbia University Department of Psychiatry

More nuanced view of brainstem neurons could lead to better drugs for depression, anxiety. Low levels of serotonin in the brain are known to play a role in depression and anxiety, and it is customary to treat these disorders with medications that increase the amount of this neurotransmitter. However, a new study suggests that this approach may be too simple. It appears that neighboring serotonin-producing brainstem regions exert different and sometimes opposing effects on behavior.

“Our study breaks with the simplistic view that ‘more is good and less is bad,’ when it comes to serotonin for mo...

Read More

Feeling Anxious? Check your Orbitofrontal Cortex, OFC, Cultivate your Optimism

Glass half full or half empty? What you see may depend in part on the size of your orbitofrontal cortex. Optimistic people also tend to be less anxious, research finds. Credit: Graphic by Julie McMahon

Glass half full or half empty? What you see may depend in part on the size of your orbitofrontal cortex. Optimistic people also tend to be less anxious, research finds. Credit: Graphic by Julie McMahon

A new study finds healthy adults who have larger OFCs tend to be more optimistic and less anxious. Anxiety disorders afflict roughly 44 million people in the U.S. These disorders disrupt lives and cost an estimated $42-$47 billion annually.

The orbitofrontal cortex, a brain region located just behind the eyes, is known to play a role in anxiety. The OFC integrates intellectual and emotional information and is essential to behavioral regulation. Previous studies have found links between the size of a person’s OFC and his or her susceptibility to anxiety...

Read More