aPKC enzymes tagged posts

Cholesterol-lowering Therapy may Hinder Aggressive Type of Colorectal Tumor

immunofluorescence image of cells labeled in green, magenta and turquoise
Multiplex immunofluorescence image of cholesterol-rich human serrated colorectal cancer. Highly aggressive tumoral cells (green and magenta) are negative for both aPKCs (turquoise). The nuclear accumulation of SREBP2 (the major enzyme of cholesterol biosynthesis) is labeled in green, and nuclei in grey. Credit: Anxo Martinez-Ordoñez

Hard-to-detect colorectal pre-cancerous lesions known as serrated polyps, and the aggressive tumors that develop from them, depend heavily on the ramped-up production of cholesterol, according to a preclinical study from researchers at Weill Cornell Medicine. The finding points to the possibility of using cholesterol-lowering drugs to prevent or treat such tumors.

In the study, published Oct...

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