artificial protein tagged posts

Synthetic Compound could serve as Prototype for Novel Class of Drugs to Treat Neurological Damage

CPTX (orange) combines functional domains present in synaptic organizing proteins in a unique way. The compound was designed to act as a universal buridge builder for excitatory connections between nerve cells. Source: DZNE/Alexander Dityatev

Researchers from the German Center for Neurodegenerative Diseases (DZNE), UK and Japan have developed a neurologically acting protein and tested it in laboratory studies. In mice, the experimental compound ameliorated symptoms of certain neurological injuries and diseases, while on the microscopic level it was able to establish and repair connections between neurons. This proof-of-principle study suggests that biologics, which act on neuronal connectivity, could be of clinical use in the long term. The results are published in the journal Science.

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‘Limitless Potential’ of Artificial Protein ushers in new era of ‘Smart’ cell therapies

Science illustration.
LOCKR in its closed (background) and open (foreground) states. A ‘key’ (black) unlocks a ‘cage’ (grey), revealing a bioactive peptide (yellow) which can interact with other molecules in the cell. More than a hundred million would be needed to cover the period at the end of this sentence. Credit: Ian Haydon / Institute for Protein Design at UW.

Transformative biotechnology lets scientists build biological circuits that give cells unprecedented capabilities. A first-of-its-kind artificial protein – designed on a computer and synthesized in the lab – can be used to build brand-new biological circuits inside living cells. These circuits transform ordinary cells into smart cells that are endowed with remarkable abilities.

Medicine has a “Goldilocks” problem...

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