Aspergillus fumigatus tagged posts

A new study led by Imperial College London finds that drug-resistant mould is spreading from the environment and infecting susceptible people’s lungs.

The researchers found six cases of people infected with a drug-resistant form of a fungi called Aspergillus fumigatus that could be traced back to spores in the environment. Their findings use samples from England, Wales, Scotland and Ireland, and are published in Nature Microbiology.

Aspergillus fumigatus is an environmental mould that can cause fungal lung disease. While people with healthy lungs clear inhaled spores, people with lung conditions or weakened immune systems sometimes cannot, meaning the spores may remain in the lungs causing an infection called aspergillosis. Aspergillosis affects 10-20 million people worldwide...

Research team clarifies the mechanism of gliotoxin, a mycotoxin from the fungus Aspergillus fumigatus. Scientists have now discovered how the fungus knocks out the immune defenses, enabling a potentially fatal fungal infection to develop. It is everywhere – and it is extremely dangerous for people with a weakened immune system. The fungus Aspergillus fumigatus occurs virtually everywhere on Earth, as a dark grey, wrinkled cushion on damp walls or in microscopically small spores that blow through the air and cling to wallpaper, mattresses and floors. Healthy people usually have no problem if spores find their way into their body, as their immune defence system will put the spores out of action...

Neta Shlezinger et al. Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death, Science (2017). DOI: 10.1126/science.aan0365

A team from U.S., Germany and Israel has found that mice are able to ward off fungal lung infections because their immune systems cause fungal spores to die. In their paper published in the journal Science, the team describes the means by which they discovered how mice are able to ward off fungal lung infections and what their findings might mean for human patients.

Most people breathe in approximately 1000 fungal spores every single day. But the means by which people ward off fungal infections in the lungs has not been understood...

Picture of A. fumigatus growth in solid blood media. White spots in wells show fungal growth while clear wells shows no growth because of SidA inhibition. Credit: Julia S. Martin del Campo

Researchers with the Virginia Tech Center for Drug Discovery have identified a compound that blocks the growth of a fungus that causes deadly lung infections and allergic reactions in people with compromised immune systems. The research team targeted the switch that allows the fungus Aspergillus fumigatus to survive in iron-deficient conditions like the human body. Specifically, they targeted an enzyme known as SidA, which is essential for the synthesis of siderophores that are made during infection to steal iron from human proteins.

Furthermore, by performing high-throughput screening in the center’s Dr...