Aspirin tagged posts

An international study of 3,396 patients with venous thromboembolism in 31 countries shows that the blood thinner rivaroxaban is just as safe as aspirin and more effective at preventing blood clots. CREDIT The Ottawa Hospital

An international research team has found that rivaroxaban is as safe as aspirin, and more effective at preventing recurrence of life-threatening blood clots in the legs and lungs, according to a study published in the New England Journal of Medicine. At least 1 out of 1,000 Canadians will experience one of these blood clots every year, a condition called venous thromboembolism. The clots can be deadly if they travel to the lungs (pulmonary embolism), and are the third most common cardiovascular cause of death after heart attack and stroke.

Venous thromboembolism is a ...

BTI Professor Daniel Klessig and lab members Research Associate Hyong Woo Choi and Postdoctoral scientist Murli Manohar.

Aspirin’s active form, salicylic acid, blocks a protein called HMGB1, which triggers inflammation in damaged tissues. The new findings may explain the disease-preventing effects of a low-dose aspirin regimen and offer hope that more effective aspirin-like drugs may be developed for a wide variety of diseases.

“We’ve identified what we believe is a key target of aspirin’s active form in the body, salicylic acid, which is responsible for some of the many therapeutic effects that aspirin has...