•Protein tyrosine phosphatase receptor δ is the orexigenic asprosin receptor
•Ptprd loss results in appetite reduction and unresponsiveness to exogenous asprosin
•AgRP neuron-specific Ptprd ablation leads to protection from diet-induced obesity
•The Ptprd ligand-binding domain functions as an appetite-suppressing therapeutic
Metabolic syndrome increases a person’s risk for diabetes, heart disease, and stroke, and includes conditions such as obesity, high blood pressure and high blood sugar...
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