astrocytes tagged posts

Manipulating Astrocytes affects Long-Term Memory, researchers discover

One of the most powerful assets of the brain is that it can store information as memories, allowing us to learn from our mistakes. However, some memories remain vivid while others become forgotten. Unlike computers, our brains appear to filter which memories are salient enough to store.

Researchers from Tohoku University have discovered that part of the memory selection process depends on the function of astrocytes, a special type of cell that surrounds neurons in the brain. They showed that artificially acidifying the astrocytes did not affect short-term memory but prevented memories from being remembered long-term.

The findings are published in the journal Glia.

The researchers implemented a technique called “optogenetics” to manipulate the astrocytes by shining light onto ...

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Key to Resilient Energy-efficient AI/machine learning may reside in Human Brain

Synchronization of neural oscillations achieved by astrocytes
Synchronization of neural oscillations is achieved by astrocytes through information sharing among their glial network. Credit: Elizabeth Floresgomez Murray. All Rights Reserved.

A clearer understanding of how a type of brain cell, astrocytes function and can be emulated in the physics of hardware devices, may result in artificial intelligence (AI) and machine learning that autonomously self-repairs and consumes much less energy than the technologies currently do, according to a team of Penn State researchers.

Astrocytes are named for their star shape and are a type of glial cell, which are support cells for neurons in the brain. They play a crucial role in brain functions such as memory, learning, self-repair and synchronization.

“This project stemmed from recent observations in...

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Cholesterol drives Alzheimer’s Plaque Formation

Amyloid plaques form among neurons in Alzheimer’s disease. New research suggests cholesterol plays a key role.

Cholesterol manufactured in the brain appears to play a key role in the development of Alzheimer’s disease, new research indicates.

Scientists from the University of Virginia School of Medicine and their collaborators found that cholesterol produced by astrocytes is required for controlling the production of amyloid beta, a sticky protein that builds up in the brains of patients with Alzheimer’s. The protein accumulates into insoluble plaques that are a hallmark of the disease. Many efforts have targeted these plaques in the hope that removing or preventing them could treat or prevent Alzheimer’s.

The new findings offer important insights into how and why the plaques for...

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Newly discovered subset of Brain Cells fight Inflammation with Instructions from the Gut

This shows the outline of a head and a brain
The researchers used refined gene- and protein-analysis tools to identify the novel astrocyte subset. Image is in the public domain

Astrocytes are the most abundant type of cells within the central nervous system (CNS), but they remain poorly characterized. Researchers have long assumed that astrocytes’ primary function is to provide nutrients and support for the brain’s more closely scrutinized nerve cells; over the years, however, increasing evidence has shown that astrocytes can also actively promote neurodegeneration, inflammation, and neurological diseases...

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