astrocytes tagged posts

Researchers in Japan have revealed a previously unknown mechanism for pain control involving a newly identified group of cells in the spinal cord, offering a potential target for enhancing the therapeutic effect of drugs for chronic pain.

While neurons may be the most well-known cells of the central nervous system, an assortment of non-neuronal cells first discovered in the mid-nineteenth century also play a wide variety of important roles.

Originally named after the Greek word for “glue,” these glial cells are now known to be much more than glue and in fact are critical elements for regulating neuronal development a...

A team led by a biomedical scientist at the University of California, Riverside has found a new mechanism responsible for the abnormal development of neuronal connections in the mouse brain that leads to seizures and abnormal social behaviors.

The researchers focused on the hippocampus, which plays an important role in learning and social interactions; and synapses, specialized contacts between neurons.

Each neuron in the brain receives numerous excitatory and inhibitory synaptic inputs...

Jason Gerstner, assistant research professor in WSU’s Elson S. Floyd College of Medicine, is lead author of a Science Advances paper describing a gene involved in the quality of sleep experienced by three different animals, including humans. Credit: Washington State University

Washington State University researchers have seen how a particular gene is involved in the quality of sleep experienced by 3 different animals, including humans. The gene and its function opens a new avenue for scientists exploring how sleep works and why animals need it so badly. As a doctoral student at the University of Wisconsin, Gerstner looked at genes that change expression over the sleep-wake cycle and found expression of the gene FABP7 changed over the day throughout the brain of mice...

In this slice of the master clock, cells expressing an astrocyte-specific structural protein that had been stained red (top right panel) matched up well with cells that had been equipped to fluoresce green when they were expressing a clock gene (middle right panel), demonstrating that the scientists could watch astrocytes tick in the clock. Credit: Herzog Lab

Until recently, work on biological clocks that dictate daily fluctuations in most body functions, including core body temperature and alertness, focused on neurons, those electrically excitable cells that are the divas of the central nervous system. Asked to define the body’s master clock, biologists would say it is the suprachiasmatic nuclei, or SCN – in the brain that consist of 20,000 neurons...