atherosclerosis tagged posts

Asam keping

Dr Suraya A. Sani, recent PhD graduate from The University of Nottingham Malaysia Campus (UNMC), has been working with a tropical fruit, locally called asam keping, under the supervision of Dr Teng-Jin Khoo at UNMC’s School of Pharmacy. Funded by the Sarawak Tunku Abdul Rahman Scholarship, she was able to spend her time on research work for the first two years at UNMC and a year working on her research at the Centre for BioMolecular Sciences at University Park, The University of Nottingham, UK under the co-supervision of Professor Dr Jonas Emsley.

Dr Suraya A. Sani conducts research on the medicinal properties of the Garcinia plant species; a plant species which is largely available in Malaysia and throughout Southeast Asia...

MCP-1 released by smooth muscle and endothelial cells promotes the recruitment of monocytes and macrophages to the subendothelial cell layer. Deposition of lipids within these monocytes and macrophages then leads to development of atherosclerotic lesions.

This is one of the 1st studies to demonstrate the effect of red blood cells on the disease and could also affect the way patients with other health conditions, like cancer, who are prone to developing cardiovascular issues, are diagnosed and treated. “White blood cells play a key role in fueling adipose tissue (fat) inflammation and insulin resistance in obesity and also promote the clogging of arteries, or atherosclerosis, setting the stage for heart attack and stroke...

Confocal fluorosence microscopy: human aortic smooth muscle cells infected with P. gingivalis

A team has shown a periodontal pathogen causes changes in gene expression that boost inflammation and atherosclerosis in aortic smooth muscle cells. The circumstantial evidence that led to this study was ample. The periodontal pathogen, Porphyromonas gingivalis, has also been found in coronary artery plaques of heart attack patients. And in 2 species of animal models, P. gingivalis has been shown to cause and accelerate formation of coronary and aortic atherosclerosis.

They began by culturing human aortic smooth muscle cells, and infecting them with P. gingivalis. They found that gingipains, virulence factors produced by P...