atorvastatin tagged posts

Cholesterol-lowering Therapy may Hinder Aggressive Type of Colorectal Tumor

immunofluorescence image of cells labeled in green, magenta and turquoise
Multiplex immunofluorescence image of cholesterol-rich human serrated colorectal cancer. Highly aggressive tumoral cells (green and magenta) are negative for both aPKCs (turquoise). The nuclear accumulation of SREBP2 (the major enzyme of cholesterol biosynthesis) is labeled in green, and nuclei in grey. Credit: Anxo Martinez-Ordoñez

Hard-to-detect colorectal pre-cancerous lesions known as serrated polyps, and the aggressive tumors that develop from them, depend heavily on the ramped-up production of cholesterol, according to a preclinical study from researchers at Weill Cornell Medicine. The finding points to the possibility of using cholesterol-lowering drugs to prevent or treat such tumors.

In the study, published Oct...

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High Cholesterol triggers Mitochondrial Oxidative Stress leading to Osteoarthritis

knee problems

Protective effects of mitochondria-targeted antioxidants and statins on cholesterol-induced osteoarthritis

High cholesterol might harm more than our cardiovascular systems. New research using animal models, published online in The FASEB Journal, suggests that high cholesterol levels trigger mitochondrial oxidative stress on cartilage cells, causing them to die, and ultimately leading to the development of osteoarthritis. This research tested the potential therapeutic role of mitochondria targeting antioxidants in high-cholesterol-induced osteoarthritis and provided proof-of-concept for the use of mitochondrial targeting antioxidants to treat osteoarthritis.

“Our team has already begun working alongside dietitians to try to educate the public about healthy eating and how to keep cholesterol...

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