autism tagged posts

Do Plastics Cause Autism? Here’s what the latest study really says

A study out recently has prompted much media attention about the role of plastics in developing autism.

In particular, the study focused on exposure to a component of hard plastics—bisphenol A, or BPA—in the womb and the risk of boys developing this neurodevelopmental disorder.

Importantly, the study doesn’t show plastics containing BPA cause autism.

But it suggests BPA might play a role in estrogen levels in infant and school-aged boys, which can then affect their chance of being diagnosed with autism.

Let’s tease out the details.

Remind me, what is BPA?
BPA is a component of hard plastics that has been used for a few decades. Because BPA is found in plastics used for food and some drink containers, many people are exposed to low levels of BPA every day.

But conc...

Read More

Mom’s Dietary Fat Rewires Male and Female Brains Differently

A microglia (in magenta) from a male mouse born to a mom on a high-fat diet, which sequesters more brain serotonin (in green) than males with mom’s eating a typical lab diet. (Bilbo Lab)
A microglia (in magenta) from a male mouse born to a mom on a high-fat diet, which sequesters more brain serotonin (in green) than males with mom’s eating a typical lab diet. (Bilbo Lab)

Excess fat triggers immune cells to overeat serotonin in the brain of developing male mice, leading to depression-like behavior. More than half of all women in the United States are overweight or obese when they become pregnant. While being or becoming overweight during pregnancy can have potential health risks for moms, there are also hints that it may tip the scales for their kids to develop psychiatric disorders like autism or depression, which often affects one gender more than the other.

What hasn’t been understood however is how the accumulation of fat tissue in mom might signal through the ...

Read More

Research confirms Gut-brain Connection in Autism

An image showing neurons in the gut of a mouse with the autism-related gene mutation. The study found mice with the mutation had more neurons in the small intestine.
An image showing neurons in the gut of a mouse with the autism-related gene mutation. The study found mice with the mutation had more neurons in the small intestine.

Up to 90% of people with autism suffer from gut problems, but nobody has known why. New research reveals the same gene mutations – found both in the brain and the gut – could be the cause.

The discovery confirms a gut-brain nervous system link in autism, opening a new direction in the search for potential treatments that could ease behavioural issues associated with autism by targeting the gut.

Chief Investigator Associate Professor Elisa Hill-Yardin, RMIT University, said scientists trying to understand autism have long been looking in the brain, but the links with the gut nervous system have only been recently ex...

Read More

Key Protein involved in the Development of Autism discovered

Raúl Méndez and Eulàlia Belloc from the Translational Control of Cell Cycle and Differentiation Lab at IRB Barcelona. Credit: IRB Barcelona

Raúl Méndez and Eulàlia Belloc from the Translational Control of Cell Cycle and Differentiation Lab at IRB Barcelona.
Credit: IRB Barcelona

The protein CPEB4, which coordinates the expression of hundreds of genes required for neuronal activity, is altered in the brains of individuals with autism, according to new research. Recent years have brought about important breakthroughs in autism research through the genetic analysis of thousands of these individuals. Researchers have been able to find correlations between defects in the expression and/or function of about 200 genes and susceptibility to autism. However, the bases underlying the dysregulation of these genes in subjects with autism were unknown.

An international team headed by José Lucas, researcher at the Spanish National Researc...

Read More