autism tagged posts

Raúl Méndez and Eulàlia Belloc from the Translational Control of Cell Cycle and Differentiation Lab at IRB Barcelona.
Credit: IRB Barcelona

The protein CPEB4, which coordinates the expression of hundreds of genes required for neuronal activity, is altered in the brains of individuals with autism, according to new research. Recent years have brought about important breakthroughs in autism research through the genetic analysis of thousands of these individuals. Researchers have been able to find correlations between defects in the expression and/or function of about 200 genes and susceptibility to autism. However, the bases underlying the dysregulation of these genes in subjects with autism were unknown.

An international team headed by José Lucas, researcher at the Spanish National Researc...

This image shows the selective response of a subplate neuron to sounds of different frequencies (horizontal axis) and volume levels (vertical axis). Warmer colors indicate a stronger response. Subplate neurons are among the first neurons to form in the cerebral cortex and were previously thought to serve a primarily structural role in brain development. A new study suggests that these neurons do, in fact, transmit sensory information. This cell only responded to higher frequencies, especially at low volume levels; increased volume expanded the cell’s frequency range of response. Prior to this study, the ability of the cortex to selectively respond to certain sounds was thought to emerge later in brain development. Credit: Patrick Kanold

Brain cells that support early structural development...

Unusually weak neural responses (yellow spot) in the anterior cingulate cortex: autistic people find it hard to imagine themselves in somebody else’s position. Credit: Joshua Balsters / ETH Zurich

Brain researchers at ETH Zurich and other universities have shown for the first time that a region of the brain associated with empathy only activates very weakly in autistic people. This knowledge could help to develop new therapies for those affected by autism. Professor Nicole Wenderoth and her senior scientist Joshua Balsters have used fMRI from autistic adolescents to discover unusual activity in a particular region of the brain, the anterior cingulate cortex (ACC).

The researchers were aware that activity in this part of the brain is coupled with the “theory of mind”, which makes it possi...

Stimulation of Dorsolateral Prefrontal Cortex Enhances Adaptive Cognitive Control: A High-Definition Transcranial Direct Current Stimulation Study Oyetunde Gbadeyan, Katie McMahon, Marco Steinhauser and Marcus Meinzer Journal of Neuroscience 14 December 2016, 36 (50) 12530-12536; DOI: https://doi.org/10.1523/JNEUROSCI.2450-16.2016

A cutting edge, non-invasive brain stimulation technique could improve cognitive control for people with conditions such as schizophrenia and autism, ADHD. Researchers at The University of Queensland’s Centre for Clinical Research have found the technique – which applies high-definition transcranial direct current stimulation to a particular area of the brain – improves cognitive and conflict control.

PhD candidate Oyetunde Gbadeyan said the study provides th...