autism tagged posts

Researchers used a common photocopy machine to measure the lengths of the index and ring fingers of 42 women. Half of these women were asked to solve different mental tasks after they had been given a drop of testosterone on their tongue. The goal was to determine the differences in how men’s and women’s brains work, and the significance of finger length and testosterone levels. Credit: Carl Pintzka / Kolbjørn Skarpnes, NTNU.

It is well-known that adults whose index finger is shorter than their ring finger were exposed to greater amounts of testosterone when they were in the womb. Both women and men with this characteristic are – on average – better equipped to solve mentally demanding 3D rotation tasks as adults...

Salk researchers have turned the skin cells of people with autism spectrum disorder into neurons. These cells show specific defects compared with those neurons derived from healthy people, including diminished ability to form excitatory connections with other neurons (indicated by red and green dots in the neuron). Credit: Salk Institute

The brains of some people with autism spectrum disorder grow faster than usual early on in life, often before diagnosis. A new study co-led by Salk Institute scientists has employed a cutting-edge stem cell technique to unravel the mechanisms driving the mysterious phenomenon of excess brain growth, which affects as many as 30% of people with autism...

Representation of the long/short polymorphism of the 5-HTT gene and the release, reception and recycling of serotonin in neurons. Adapted from Canli and Lesch

Stress during pregnancy has been linked to several conditions, including some instances of autism spectrum disorder. Now, researchers at the Uni of Missouri School of Medicine have observed a variant of a stress-sensitive gene and exposure to stress during pregnancy among two groups of mothers of children with autism. The researchers believe the finding could be a step toward helping identify women who have greater risks for having children with autism when exposed to stressors during a specific time window during pregnancy.

“Autism was thought to be largely a genetic disorder, but previous research has shown that environmental influ...

Image: Based upon conserved snoRNA sequence elements, this large population of guide RNAs has been divided into two major families designated the box C/D and the box H/ACA snoRNAs. The primary function of the box C/D snoRNAs is to guide 2′-O-methylation of targeted rRNA nucleotides while the box H/ACA snoRNAs direct the conversion of specific uridine residues to pseudouridine.

Scientists have discovered unexpected functions of small nucleolar RNAs (snoRNAs) that explain the cause of some genetic diseases and cancers. However, it is not clear how the change in snoRNA expression could lead to these diseases. Using RNA sequencing and molecular biology techniques, researchers found snoRNAs not only modify ribosomes, but can also regulate alternative splicing...