Autoimmune tagged posts

Body Versus Brain: New evidence for an Autoimmune cause of Schizophrenia

Cell-based assay to detect the anti-NCAM1 autoantibody
NCAM1 is induced only in green cells (HeLa cells). Serum from patients with anti-NCAM1 autoantibody react only to green cells (framed in red).

Researchers have found that some people with schizophrenia have autoantibodies — which are made by the immune system and recognize the body’s own proteins, rather than outside threats such as viruses or bacteria — against NCAM1, a protein that’s importa.nt for communication between brain cells. The patients’ autoantibodies also caused schizophrenia-related behaviors in mice. These findings may improve the diagnosis and treatment of a subset of patients with schizophrenia.

Schizophrenia is a disorder that affects how people act, think, and perceive reality...

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Fibromyalgia likely the result of Autoimmune Problems

Passive transfer of fibromyalgia symptoms from patients to miceJournal of Clinical Investigation, 2021; 131 (13) DOI: 10.1172/JCI144201

New research from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King’s College London, in collaboration with the University of Liverpool and the Karolinska Institute, has shown that many of the symptoms in fibromyalgia syndrome (FMS) are caused by antibodies that increase the activity of pain-sensing nerves throughout the body.

The results show that fibromyalgia is a disease of the immune system, rather than the currently held view that it originates in the brain.

The study, published today in the Journal of Clinical Investigation, demonstrates that the increased pain sensitivity, muscle weakness, reduced movement, and reduc...

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