axonal sprouting tagged posts

Alzheimer Disease Pathology and Site of Gene Delivery in a Patient 7 Years After Gene Transfer Credit: http://archneur.jamanetwork.com/article.aspx?articleid=2427383

The affected neurons displayed heightened growth, axonal sprouting and activation of functional markers after nerve growth factor (NGF) was injected into their brains.The findings are derived from postmortem analyses of 10 patients who participated in phase I clinical trials launched in 2001 to assess whether injected NGF – a protein essential to cellular growth, maintenance and survival – might safely slow or prevent neuronal degeneration in patients with AD.

Cholinergic Neuronal Hypertrophy and Sprouting Credit: http://archneur.jamanetwork.com/article.aspx?articleid=2427383

Administering NGF directly into the brain – a fir...