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    Blood-Brain Barrier breakthrough reported

    April 8, 2016, Categories  Biology/Biotechnology, Health/Medical

    Cornell researchers found that an FDA-approved drug called Lexiscan activates receptors -- called adenosine receptors -- that are expressed on BBB cells. Credit: Dr. Margaret Bynoe, College of Veterinary Medicine at Cornell University

    Cornell researchers found that an FDA-approved drug called Lexiscan activates receptors — called adenosine receptors — that are expressed on BBB cells. Credit: Dr. Margaret Bynoe, College of Veterinary Medicine at Cornell University

    Cornell researchers have discovered a way to penetrate the blood brain barrier (BBB) that may soon permit delivery of drugs directly into the brain to treat disorders such as Alzheimer’s disease and chemotherapy-resistant cancers. The BBB is a layer of endothelial cells that selectively allow entry of molecules needed for brain function, such as amino acids, oxygen, glucose and water, while keeping others out. An FDA-approved drug, Lexiscan activates adenosine receptors – that are expressed on these BBB cells.

    “We can open the BBB for a brief window of time, lo...

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    Drug Delivery Technique Bypasses BBB may help many patients with Neurological Conditions

    October 20, 2015, Categories  Biology/Biotechnology, Environment/Geology, Health/Medical

    Drugs used to treat a variety of central nervous system diseases may be administered through the nose and diffused through an implanted mucosal graft (A, in red) to gain access to the brain. Under normal circumstances, there are multiple layers within the nose that block the access of pharmaceutical agents from getting to the brain including bone and the dura/arachnoid membrane, which represents part of the blood-brain barrier (B). After endoscopic skull base surgery (C), all of these layers are removed and replaced with a nasal mucosal graft, which is 1,000 times more porous than the native blood-brain barrier. Consequently, these grafts may be used to deliver very large drugs, including proteins, which would otherwise be blocked by the blood-brain barrier. Credit: Garyfallia Pagonis and Benjamin S. Bleier, M.D.

    Drugs used to treat a variety of central nervous system diseases may be administered through the nose and diffused through an implanted mucosal graft (A, in red) to gain access to the brain. Under normal circumstances, there are multiple layers within the nose that block the access of pharmaceutical agents from getting to the brain including bone and the dura/arachnoid membrane, which represents part of the blood-brain barrier (B). After endoscopic skull base surgery (C), all of these layers are removed and replaced with a nasal mucosal graft, which is 1,000 times more porous than the native blood-brain barrier. Consequently, these grafts may be used to deliver very large drugs, including proteins, which would otherwise be blocked by the blood-brain barrier...

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