Functioning human pancreatic cells after they’ve been transplanted into a mouse are shown. Credit: Saiyong Zhu
When transplanted into mice, the cells protected them from developing diabetes in a mouse model of the disease by producing insulin in response to changes in glucose levels. The new study also presents significant advancements in cellular reprogramming technology, which will allow scientists to efficiently scale up pancreatic cell production and manufacture trillions of the target cells in a step-wise, controlled manner. This accomplishment opens the door for disease modeling and drug screening and brings personalized cell therapy a step closer.
“Our results demonstrate for the first time that human adult skin cells can be used to efficiently and rapidly generate functional pancr...
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