biologics tagged posts

UW Scientists use Tardigrade Proteins for Human Health breakthrough

man and woman working with lab equipment
UW student Maxwell Packebush, of Littleton, Colo., works with Silvia Sanchez-Martinez, a senior research scientist, to purify one of the tardigrade proteins used in a study showing that the proteins can be used to stabilize an important pharmaceutical for people with hemophilia and other conditions without the need for refrigeration. (Thomas Boothby Photo)

University of Wyoming researchers’ study of how microscopic creatures called tardigrades survive extreme conditions has led to a major breakthrough that could eventually make life-saving treatments available to people where refrigeration is not possible.

Thomas Boothby, an assistant professor of molecular biology, and colleagues have shown that natural and engineered versions of tardigrade proteins can be used to stabilize an impo...

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Synthetic Compound could serve as Prototype for Novel Class of Drugs to Treat Neurological Damage

CPTX (orange) combines functional domains present in synaptic organizing proteins in a unique way. The compound was designed to act as a universal buridge builder for excitatory connections between nerve cells. Source: DZNE/Alexander Dityatev

Researchers from the German Center for Neurodegenerative Diseases (DZNE), UK and Japan have developed a neurologically acting protein and tested it in laboratory studies. In mice, the experimental compound ameliorated symptoms of certain neurological injuries and diseases, while on the microscopic level it was able to establish and repair connections between neurons. This proof-of-principle study suggests that biologics, which act on neuronal connectivity, could be of clinical use in the long term. The results are published in the journal Science.

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