Biomarkers tagged posts

Improving Access to Heart-Failure Screening with Saliva

Spit to save lives: 15-minute saliva test detects heart failure at home
A new saliva-based test for heart failure measures two biomarkers from a drop of saliva in about 15 minutes and can be administered at home.

Heart failure is a leading cause of death worldwide and is especially deadly for people who don’t have access to medical facilities. A team of researchers aims to bring heart failure screening from the lab to the home with a point-of-care electrochemical biosensor prototype that measures levels of two biomarkers for heart failure in as little as 15 minutes from just a drop of saliva.

Trey Pittman, a graduate student at Colorado State University, will present his team’s research at the fall meeting of the American Chemical Society (ACS).

“Our device would be ideal for people who are at high risk for heart failure but have limited access to a ...

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New Alzheimer’s Disease Pathways identified

New Alzheimer's disease pathways identified
Path model of main findings. This path model summarizes the main-effect mediation model. Circles indicate principal components or latent variables, rectangles represent observed variables. Arrows either indicate PC loadings or structural regression paths. Thicker lines correspond to stronger loadings, solid structural paths are genome-wide significant (p < 5 × 10−8), and dashed lines are suggestive (p < 0.008). Coefficients indicate either the effect of one effect allele on a biomarker PC in SD, or the effect of one SD higher biomarker PC score on latent AD in SD. Note: all paths are adjusted for assessment age, sex, genetic ancestry, and study but are omitted from figure. Credit: Genome Medicine (2023). DOI: 10.1186/s13073-023-01233-z

Dementia, which includes Alzheimer’...

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Simple Blood Test may Predict Future Heart, Kidney Risk for people with Type 2 Diabetes

blood draw - man
blood draw – man
copyright American Heart Association

An analysis of a clinical trial of more than 2,500 people with Type 2 diabetes and kidney disease found that high levels of four biomarkers are strongly predictive for the development of heart and kidney issues.

A simple blood test may predict the risk of progressive heart and kidney disease in people with Type 2 diabetes and kidney disease, according to new research published today in the American Heart Association’s flagship journal Circulation.

“High levels of certain biomarkers are indicators of heart and kidney complications and may help predict future risk of disease progression,” said lead author James Januzzi, M.D...

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Researchers find a New Class of Biomarkers to Predict Treatment Outcomes in Cancer Patients

Researchers find a new of biomarkers to predict treatment outcomes in cancer patients
Cancer is the result of the uncontrolled division and spread of cells into surrounding tissue. Recently researchers have begun to focus on biomarkers as a source of information about different cancers, how they work in the body, and how they can be fought. Credit: Colin Behrens/Pixabay, CC0 Public Domain

One of the big reasons that cancer is difficult to treat is that patients respond to treatments differently, and these differences can rarely be anticipated. In most cases, determining whether and how a patient will respond to any given therapy requires administering it to the patient and then waiting and watching. That is a lot of pressure for researchers and physicians and a lot of risk for cancer patients, and added expense.

If a patient’s response were predictable, optimal thera...

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