biomaterials tagged posts

Signpost of cancer linked to wound-healing properties

Graphic illustration of a person's upper torso, as seen from the back, with red color and white dots and lines centered on an area to indicate pain.
ASU researchers Jordan Yaron and Kaushal Rege have found that the previously mysterious protein SerpinB3 plays a vital role in the body’s natural wound-healing process. Their findings could lead to better treatments for hard-to-heal wounds and open new avenues for tackling cancer and other diseases. Graphic by Jason Drees/ASU

SerpinB3 turns out to be both a healing powerhouse and a cancer accomplice—revealing new possibilities for medicine. Researchers have uncovered that SerpinB3, typically linked to severe cancers, is also a key player in natural wound healing. The protein drives skin cell movement and tissue rebuilding, especially when paired with next-generation biomaterial dressings...

Read More

Bacteria ‘Nanowires’ could help Develop Green Electronics

Bacteria 'nanowires' could help develop green electronics
Structure of γPFD filaments and incorporation of heme to make conductive nanowires. a) Filament assembly of γPFD through β-sheet domains, and b) proposed binding of heme molecules to the coiled-coil domains to form γPFD-heme nanowires. c) Protein-ligand binding isotherm with 30 µm of γPFD and varying concentration of heme, which indicates a stochiometric ratio of ≈1 heme per γPFD subunit in filaments. d) TEM image of the γPFD-heme nanowires. Credit: Small (2024). DOI: 10.1002/smll.202311661

Engineered protein filaments originally produced by bacteria have been modified by scientists to conduct electricity...

Read More

First-ever Spider Glue Genes Sequenced, paving way to next Biomaterials breakthrough

Aggregate spider glue from three spider types. (A) Orb weavers coat their web’s sticky capture spiral with glue, (B) cobweb weavers cover the lower portion of their triplines with glue to create ’gumfoot’ threads, (C) the bolas spider creates a large droplet of glue specialized for capturing moths, and (D) A stretching glue droplet after contacting a probe that was subsequently withdrawn at a constant rate. Inset images courtesy of Brent Opell.

Huge spider glue genes proved exceptionally challenging to sequence, could lead to organic pest control and more. Researchers have determined the first-ever complete sequences of two spider glue genes...

Read More

3D Bioprinting technique could create Artificial Blood Vessels, Organ Tissue

Orthogonal programming of matrix stiffness and geometry via oxygen inhibition-assisted stereolithography.

Orthogonal programming of matrix stiffness and geometry via oxygen inhibition-assisted stereolithography.

University of Colorado Boulder engineers have developed a 3D printing technique that allows for localized control of an object’s firmness, opening up new biomedical avenues that could one day include artificial arteries and organ tissue. The study, which was recently published in the journal Nature Communications, outlines a layer-by-layer printing method that features fine-grain, programmable control over rigidity, allowing researchers to mimic the complex geometry of blood vessels that are highly structured and yet must remain pliable.

The findings could one day lead to better, more personalized treatments for those suffering from hypertension and other vascular diseases...

Read More