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    Long-sought Structure of Telomerase Paves way for New Drugs for Aging, Cancer

    April 26, 2018, Categories  Biology/Biotechnology, Health/Medical

    Shown is the space-filling model of human telomerase holoenzyme structure determined by cryo-electron microscopy (cryo-EM). Telomerase catalyzes the synthesis of telomeric DNA (green) at the ends of chromosomes (blue) to compensate for the loss of telomeres during genome replication. The structure comprises two lobes with distinct functionalities: the catalytic core (purple) responsible for DNA synthesis and an H/ACA ribonucleoprotein lobe (cyan, teal and light green) important for telomerase biogenesis and localization to the Cajal body (red dots and lower left in closeup). Given that telomerase regulation is implicated in cancer and aging, this first architectural visualization of human telomerase represents an important breakthrough in the telomerase field and telomerase-based therapeutic design. Credit: Janet Iwasa

    Shown is the space-filling model of human telomerase holoenzyme structure determined by cryo-electron microscopy (cryo-EM). Telomerase catalyzes the synthesis of telomeric DNA (green) at the ends of chromosomes (blue) to compensate for the loss of telomeres during genome replication. The structure comprises two lobes with distinct functionalities: the catalytic core (purple) responsible for DNA synthesis and an H/ACA ribonucleoprotein lobe (cyan, teal and light green) important for telomerase biogenesis and localization to the Cajal body (red dots and lower left in closeup)...

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